Mathematical Models of Cancer Cell Plasticity
نویسندگان
چکیده
منابع مشابه
Mathematical models of cancer metabolism.
Metabolism is essential for life, and its alteration is implicated in multiple human diseases. The transformation from a normal to a cancerous cell requires metabolic changes to fuel the high metabolic demands of cancer cells, including but not limited to cell proliferation and cell migration. In recent years, there have been a number of new discoveries connecting known aberrations in oncogenic...
متن کاملMathematical models of cancer dormancy.
The objective of this paper is to present preliminary mathematical models of the interaction between tumor and antibody for the murine BCL1 lymphoma and illustrate how this interaction leads to dormancy of the tumor. We explicitly model the induction by the immune response of cell cycle arrest and apoptosis of the tumor cells. In the absence of large amounts of quantitative data and because the...
متن کاملMathematical models on cancer progression
The Cancer Stem Cell (CSC) involvement into tumor progression, tumor recurrence, and therapy resistance is one of the most studied subject of current cancer research [10,4,8,6]. Nevertheless, due to the complex dynamics characterizing the CSC tumor, a comprehensive theory has not been established yet. To this end, some advises can be obtained combining mathematical modeling and experimental dat...
متن کاملPredictive mathematical models of cancer signalling pathways.
Complex intracellular signalling networks integrate extracellular signals and convert them into cellular responses. In cancer cells, the tightly regulated and fine-tuned dynamics of information processing in signalling networks is altered, leading to uncontrolled cell proliferation, survival and migration. Systems biology combines mathematical modelling with comprehensive, quantitative, time-re...
متن کاملMathematical models of cancer stem cells.
Human cancers are thought to be sustained in their growth by a pathologic counterpart of normal adult stem cells: cancer stem cells. This concept was first developed in human myeloid leukemias and is today being extended to solid tumors such as breast and brain cancers. A quantitative understanding of cancer stem cells requires a mathematical framework to describe the dynamics of cancer initiat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Oncology
سال: 2019
ISSN: 1687-8450,1687-8469
DOI: 10.1155/2019/2403483